华人医生数据库 Chinese Medical School Graduates Gathering in North American

其他信息

专业认证： Board Certified in Pathology AP/CP, Hemapathology

科学博士：  University of Miami, 1994

科研兴趣： 1) functional genomics and biomarkers of lymphoma; including microRNA
expression profile in selected lymphoma subtypes (mantle cell lymphoma and viral-associated lymphomas) to determine possible
involvement of microRNAs in the pathogenesis of non-Hodgkin lymphoma and their possible role in diagnosis, prognosis and
therapeutic target discovery, 2) microenvironment regulation of molecular pathogenesis of lymphoma; his laboratory is studying the
normal development of germinal center B cells.His team aims to determine microenvironment regulation of normal and abnormal
transcriptional factors and miRNAs involved in B-cell differentiation, activation and lymphomagenesis, 3) Microenvironment
regulation of drug resistance of lymphoma. The team¡¯s recent studies have shown that adhesion of lymphoma cells to bone marrow
stromal cells significantly increases cellular resistance to a variety of cytotoxic drugs and induces cell cycle arrest.
They have extended this research to determine the role of the interaction between lymph node stromal cell and lymphoma cells as
well as miRNAs in response to therapy and to further elucidate the molecular mechanisms by which stroma regulates lymphoma cell
survival.