Chinese Doctors Directory Chinese Medical School Graduates Gathering in North America

Additional Information

Sub-Specialty: Gastrointestinal Pathology

Clinical Interests: Weibiao Cao studies the signal transduction pathways mediating
contraction in
normal esophageal smooth muscle and the inflammation-associated changes in signaling that occur in
experimental esophagitis. His findings show that a low molecular weight phospholipase A2 (type I)
mediates cat and human in vitro lower esophageal sphincter tone by producing arachidonic acid, which
is metabolized to prostaglandin F2alpha and thromboxane A2. These arachidonic acid metabolites act
on receptors linked to Gi3 and Gq proteins to activate phospholipases, producing second messengers,
and maintaining LES tone.